| Identification | Back Directory | [Name]
2'-O-Propygylguanosine | [CAS]
206552-86-5 | [Synonyms]
2'-O-Propygylguanosine
2’-O-(2-Propyn-1-yl)guanosine
Guanosine, 2'-O-2-propyn-1-yl- | [Molecular Formula]
C13H15N5O5 | [MDL Number]
MFCD28976131 | [MOL File]
206552-86-5.mol | [Molecular Weight]
321.29 |
| Chemical Properties | Back Directory | [density ]
1.76±0.1 g/cm3(Predicted) | [pka]
9?+-.0.20(Predicted) | [InChI]
InChI=1S/C13H15N5O5/c1-2-3-22-9-8(20)6(4-19)23-12(9)18-5-15-7-10(18)16-13(14)17-11(7)21/h1,5-6,8-9,12,19-20H,3-4H2,(H3,14,16,17,21)/t6-,8-,9-,12-/m1/s1 | [InChIKey]
VBIXIAQUDWOPDT-WOUKDFQISA-N | [SMILES]
OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](OCC#C)[C@@H]1O |
| Hazard Information | Back Directory | [Description]
2′-O-2-Propyn-1-ylguanosine (2'-O-Propygylguanosine) is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7). 2′-O-2-Propyn-1-ylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
| [Solubility in organics]
10 mM in DMSO
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