| Identification | Back Directory | [Name]
IMP-1088 | [CAS]
2059148-82-0 | [Synonyms]
IMP-1088
IMP-1088;IMP1088;IMP 1088
1H-Indazole-3-methanamine, 5-[3,4-difluoro-2-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy]phenyl]-N,N,1-trimethyl- | [Molecular Formula]
C25H29F2N5O | [MDL Number]
MFCD32708500 | [MOL File]
2059148-82-0.mol | [Molecular Weight]
453.53 |
| Chemical Properties | Back Directory | [Boiling point ]
566.9±50.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Methyl Acetate: 10 mg/ml | [form ]
Solid | [pka]
7.73±0.28(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a Kd of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection[1]. | [References]
[1] Aurélie Mousnier, et al. Fragment-derived Inhibitors of Human N-myristoyltransferase Block Capsid Assembly and Replication of the Common Cold Virus. Nat Chem. 2018 Jun;10(6):599-606. DOI:10.1038/s41557-018-0039-2 |
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