| Identification | Back Directory | [Name]
Azido-PEG3-S-PEG4-propargyl | [CAS]
2055041-24-0 | [Synonyms]
Azido-PEG3-S-PEG4-propargyl | [Molecular Formula]
C19H35N3O7S | [MDL Number]
MFCD29918240 | [MOL File]
2055041-24-0.mol | [Molecular Weight]
449.562 |
| Hazard Information | Back Directory | [Description]
Azido-PEG3-S-PEG4-propargyl is a crosslinker containing a propargyl group and an azide group. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The azide group enables PEGylation via Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
Azido-PEG3-S-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-S-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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