| Identification | Back Directory | [Name]
Propargyl-PEG4-Sulfone-PEG4-t-butyl ester | [CAS]
2055024-43-4 | [Synonyms]
Propargyl-PEG4-Sulfone-PEG4-Boc
Propargyl-PEG4-Sulfone-PEG4-t-butyl ester
4,7,10,13,19,22,25,28-Octaoxa-16-thiahentriacont-30-ynoic acid, 1,1-dimethylethyl ester, 16,16-dioxide | [Molecular Formula]
C26H48O12S | [MDL Number]
MFCD30182061 | [MOL File]
2055024-43-4.mol | [Molecular Weight]
584.72 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG4-Sulfone-PEG4-t-butyl ester is a PEG linker containing a propargyl group and t-butyl protected carboxyl group acid. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The t-butyl protected carboxyl group (COOH) prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling conditions. The protected acid can be deprotected by acidic or basic hydrolysis. The hydrophilic PEG spacer increases solubility in aqueous media. |
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