| Identification | Back Directory | [Name]
AZD9898 | [CAS]
2042347-69-1 | [Synonyms]
AZD9898
Cyclopropanecarboxylic acid, 2-[[5-[(5-chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxy-2-pyrazinyl]carbonyl]-, (1S,2S)- | [Molecular Formula]
C20H19ClF3N3O4 | [MDL Number]
MFCD32201104 | [MOL File]
2042347-69-1.mol | [Molecular Weight]
457.83 |
| Chemical Properties | Back Directory | [Boiling point ]
633.8±55.0 °C(Predicted) | [density ]
1.463±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.58±0.11(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma[1].
AZD9898 with the single dose of 100 mg/kg is well tolerated and no safety concerns are raised[1]. | [References]
[1]. Munck Af Rosensch?ld M, et al. Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma. J Med Chem. 2019 Aug 30. |
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DC Chemicals
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