| Identification | Back Directory | [Name]
FR-194921 | [CAS]
202646-80-8 | [Synonyms]
FR-194921
FR194921 >=98% (HPLC)
3(2H)-Pyridazinone, 2-(1-methyl-4-piperidinyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)- | [Molecular Formula]
C23H23N5O | [MDL Number]
MFCD27965870 | [MOL File]
202646-80-8.mol | [Molecular Weight]
385.46 |
| Chemical Properties | Back Directory | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear (warmed) | [form ]
Solid | [pka]
8.51±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
FR194921 is a blood-brain barrier-permeable A1R adenosine receptor antagonist. The measured Ki values of FR194921 for the human adenosine A1 receptors have been in the low nM range with no binding affinity for A2A and A3 receptors up to 1μM. It is orally active and has good bioavailability. FR194921 was used in a recent study to restore auditory cortex plasticity. Paired with sound exposureFR194921 resulted in cortical map plasticity and improved auditory perception in adult mice. |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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