| Identification | Back Directory | [Name]
perlapine | [CAS]
1977-11-3 | [Synonyms]
HF 2333
Hypnodin
AW 14-2333
6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepin
6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine
11H-Dibenz[b,e]azepine, 6-(4-methyl-1-piperazinyl)-
6-(4-methylpiperazin-1-yl)-11H-benzo[c][1]benzazepine | [Molecular Formula]
C19H21N3 | [MDL Number]
MFCD00867539 | [MOL File]
1977-11-3.mol | [Molecular Weight]
291.39 |
| Chemical Properties | Back Directory | [Melting point ]
136-138° | [Boiling point ]
423.4°C (rough estimate) | [density ]
1.0521 (rough estimate) | [refractive index ]
1.6080 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 5 mg/ml | [form ]
A crystalline solid | [pka]
8.00±0.20(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Uses]
Perlapine exhibits antipsychotic activity and blocks dopamine and serotonin receptors. Perlapine is also a novel agonist of hM3Dq, a designer receptor exclusively activated by designer drugs (DREADD). | [Uses]
Perlapine is an atypical neuroleptic that blocks dopamine and serotonin (5-HT) receptors (Kis = 60, 30, and 30 nM for D2, D4, and 5-HT2A, respectively). Perlapine is also an agonist for hM3Dq, a designer receptor exclusively activated by designer drugs (DREADD) derived from the human muscarinic acetylcholine M3 receptor that activates neuronal firing. Perlapine displays >10,000-fold selectivity for hM3Dq over hM3. | [Definition]
ChEBI: Perlapine is an organic molecular entity. | [storage]
Store at -20°C |
| Safety Data | Back Directory | [Toxicity]
LD50 in male, female mice, rats (mg/kg): 61, 61, 60, 66 i.v.; 250, 300, 480, 420 s.c., 270, 280, 660, 720 orally (Yokotani) |
|
| Company Name: |
Energy Chemical
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http://www.energy-chemical.com |
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R&D Systems, Inc
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www.rndsystems.com |
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Biorbyt Ltd.
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www.biorbyt.com |
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CHEMICAL LAND21
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