| Identification | Back Directory | [Name]
4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl | [CAS]
1957236-36-0 | [Synonyms]
Pomalidomide-NH2
Pomalidomide-C8-NH2
Thalidomide-NH-C8-NH2
4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
1H-Isoindole-1,3(2H)-dione, 4-[(8-aminooctyl)amino]-2-(2,6-dioxo-3-piperidinyl)-
4-((8-aminooctyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride | [Molecular Formula]
C21H28N4O4 | [MOL File]
1957236-36-0.mol | [Molecular Weight]
400.47 |
| Hazard Information | Back Directory | [Description]
Thalidomide-NH-C8-NH2 is a Thalidomide -based cereblon ligand with a linker, which is a useful precursor for synthesis of PROTAC degraders. Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. PROTAC degraders are usually heterobifunctional small molecules consisting of two ligands joined by a linker: one ligand recruits and binds a protein of interest (POI) while the other recruits and binds an E3 ubiquitin ligase. Simultaneous binding of the POI and ligase by the PROTAC induces ubiquitylation of the POI and its subsequent degradation by the ubiquitin–proteasome system (UPS), after which the PROTAC is recycled to target another copy of the POI. |
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ChemShuttle, Inc.
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0510-83588313-802 18800520310; |
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https://www.jiehuapharma.com/ |
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HitGen Inc.
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028-85197385 13618381045 |
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https://www.hitgen.com/ |
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Pharmalego
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13472578225 18321033991 |
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https://cn.pharmalego.com/ |
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