| Identification | Back Directory | [Name]
17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester | [CAS]
195503-20-9 | [Synonyms]
SPNWWFJGYHYDNY-HCAGXNQISA-N
17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester
17-trifluoromethylphenyl trinor Prostaglandin F2.alpha. methyl ester
17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester Exclusive | [Molecular Formula]
C25H33F3O5 | [MOL File]
195503-20-9.mol | [Molecular Weight]
470.52 |
| Hazard Information | Back Directory | [Description]
Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.1,2,3 17-trifluoromethylphenyl trinor PGF2α is an analog of PGF2α that shares the meta-trifluoromethyl group of travoprost with the 17-phenyl trinor modification of latanoprost. It is anticipated to be a potent and selective agonist of the FP receptor, with potential applications in glaucoma and luteolysis. 17-trifluoromethylphenyl trinor PGF2α methyl ester is a lipophilic analog of 17-trifluoromethylphenyl trinor PGF2α. Methyl esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid. | [References]
1. Samuelsson, B., Goldyne, M., Granstr?m, E., et al. Prostaglandins and thromboxanes Annu. Rev. Biochem. 47,997-1029(1978).
2. Speroff, L., and Ramwell, P.W. Prostaglandins in reproductive physiology Am. J. Obstet. Gynecol. 107(7),1111-1130(1970).
3. Crankshaw, D.J., and Gaspar, V. Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes J. Reprod. Fertil. 103(1),55-61(1995). |
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