| Identification | Back Directory | [Name]
Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl- | [CAS]
1954650-11-3 | [Synonyms]
JMS-053
Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl-
JMS-053 7-Imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione | [Molecular Formula]
C13H8N2O2S | [MDL Number]
MFCD32206721 | [MOL File]
1954650-11-3.mol | [Molecular Weight]
256.28 |
| Hazard Information | Back Directory | [Description]
JMS-053 is a potent inhibitor of the dual specificity phosphatase PTP4A3 that is potentially suitable for cancer therapy. JMS-053 markedly enhanced microvascular barrier function after exposure of endothelial cells to vascular endothelial growth factor or lipopolysaccharide. JMS-053 also blocked the concomitant increase in RhoA activation and loss of Rac1. In human ovarian cancer cells, JMS-053 impeded migration, disrupted spheroid growth, and decreased RhoA activity. Importantly, JMS-053 displayed anticancer activity in a murine xenograft model of drug resistant human ovarian cancer. |
|
|