| Identification | Back Directory | [Name]
Amino-PEG4-CH2CO2H | [CAS]
195071-49-9 | [Synonyms]
Amino-PEG4
195071-49-9
H2N-PEG4-CH2COOH
NH2-PEG4-CH2COOH
AMINE-PEG4-CH2COOH
Amino-PEG4-CH2CO2H
Amino-PEG4-CH2COOH
Amino-PEG4-CH2CO4H
Amino-PEG4-acetic acid
α-Amino-ω-carboxyl poly(ethylene glycol)
14-amino-3,6,9,12-tetraoxatetradecanoic acid
3,6,9,12-Tetraoxatetradecanoic acid, 14-amino-
2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]aceticacid
Acetic acid, 2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]- | [Molecular Formula]
C10H21NO6 | [MDL Number]
MFCD27977508 | [MOL File]
195071-49-9.mol | [Molecular Weight]
251.28 |
| Chemical Properties | Back Directory | [Boiling point ]
397.6±32.0 °C(Predicted) | [density ]
1.156±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 100 mg/mL (397.96 mM; Need ultrasonic) | [form ]
solid | [pka]
3.39±0.10(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Description]
Amino-PEG4-CH2CO2H is a PEG linker containing an amino group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. | [Uses]
Amino-PEG4-CH2CO2H is an important biological reagent for the synthesis of PROTAC and antibody-drug couplings (ADCs). It is also used to prepare Masp inhibitory compounds, Mertk degraders and pyruvate kinase inhibitors. |
|
|