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ChemicalBook--->CAS DataBase List--->194935-38-1

194935-38-1

194935-38-1 Structure

194935-38-1 Structure
IdentificationBack Directory
[Name]

DINOPROSTONE ETHANOLAMIDE
[CAS]

194935-38-1
[Synonyms]

PGE2-EA
DINOPROSTONE ETHANOLAMIDE
PROSTAGLANDIN E2 ETHANOLAMIDE
Prostaglandin E2 Ethanolamide Exclusive
Prostaglandin E2 Ethanolamide MaxSpecStandard
Prostaglandin E2 Ethanolamide Lipid Maps MS Standard
N-(2-HYDROXYETHYL)-9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-AMIDE
(Z)-N-(2-hydroxyethyl)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enamide
[Molecular Formula]

C22H37NO5
[MDL Number]

MFCD00797645
[MOL File]

194935-38-1.mol
[Molecular Weight]

395.53
Chemical PropertiesBack Directory
[Boiling point ]

611.5±55.0 °C(Predicted)
[density ]

1.134±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C
[form ]

powder
[pka]

13.79±0.60(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]


GHS02,GHS07
[Signal word ]

Danger
[Hazard statements ]

H225-H319
[Precautionary statements ]

P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501
Hazard InformationBack Directory
[Description]

Prostaglandin E2 ethanolamide (PGE2-EA) is an analog of PGE2 with improved water solubility and stability. PGE2-EA is formed via COX-2 metabolism of arachidonoyl ethanolamide (AEA; ) and acts as an agonist at E prostanoid (EP) receptors 1-4 (Kis = 2.45, 0.46, 0.2, and 0.51 μM, respectively). It also inhibits indoleamine 2,3-dioxygenase-1 (IDO-1) in THP-1 cells and human monocytes (IC50s = 5.7 and 4.7 μM, respectively). PGE2-EA (10 μM) prevents morphological changes and F-actin rearrangement as well as reduces L-homocysteine-induced NLRP3 inflammasome formation and activation in podocytes. Ex vivo, PGE2-EA reduces luminal damage and lymphocyte infiltration in a human mucosal explant colitis model.
[Uses]

Prostaglandin E2 Ethanolamide-d4 is the isotope labelled analogue of Prostaglandin E2 Ethanolamide, an analogue of Prostaglandin E2 (P838610). Prostaglandin E2 is most common and most biologically potent of mammalian prostaglandins.
[Definition]

ChEBI: Prostaglandin E2 ethanolamide is a prostanoid.
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