| Identification | Back Directory | [Name]
2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE | [CAS]
194085-75-1 | [Synonyms]
YKP 509
RWJ 333369
Carisbamate
JNJ 10234094
(S)-Carisbamate
CarisbaMate (RWJ-333369)
2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE
[(2S)-2-(2-chlorophenyl)-2-hydroxyethyl] carbamate
1,2-ETHANEDIOL,1-(2-CHLOROPHENYL)-, 2-CARBAMATE, (S)-
1,2-Ethanediol,1-(2-chlorophenyl)-, 2-carbaMate, (1S)- | [Molecular Formula]
C813CH8D2Cl15NO3 | [MDL Number]
MFCD15071195 | [MOL File]
194085-75-1.mol | [Molecular Weight]
215.63 |
| Chemical Properties | Back Directory | [Melting point ]
131-132°C | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Description]
Carisbamate is an antiepileptic agent., In vivo, administration of carisbamate (10-60 mg/kg) dose-dependently reduces spike and wave discharges in the frontoparietal cortex in a rat model of absence seizures. Carisbamate (10 mg/kg) increases latency to the first running episode in the Wistar audiogenic sensitive rat model of convulsive seizures. It also reduces motor seizure frequency in a rat model of spontaneous seizures in a dose-dependent manner. Carisbamate blocks Nav1.2 channels (IC50 = 68 μM for rat channels) and inhibits repetitive firing of action potentials in rat hippocampal neurons in a dose-dependent manner. It also reduces T-type Ca2+ currents in HEK cells transfected with human recombinant Cav3.1 channels at a concentration of 300 μM. | [Uses]
Carisbamate is being developed for adjuvant treatment of partial onset epilepsy. Carisbamate produces anticonvulsant effects in primary generalized, complex partial and absence-type seizure models, an
d exhibits neuroprotective and antiepileptogenic properties in rodent epilepsy models. | [Uses]
Carisbamate is being developed for adjuvant treatment of partial onset epilepsy. Carisbamate produces anticonvulsant effects in primary generalized, complex partial and absence-type seizure models, and exhibits neuroprotective and antiepileptogenic properties in rodent epilepsy models. | [Uses]
Labelled Carisbamate; it is being developed for adjuvant treatment of partial onset epilepsy. Carisbamate produces anticonvulsant effects in primary generalized, complex partial and absence-type seizu
re models, and exhibits neuroprotective and antiepileptogenic properties in rodent epilepsy models. | [Definition]
ChEBI: Carisbamate is an organochlorine compound. | [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|