| Identification | Back Directory | [Name]
SC 19220 | [CAS]
19395-87-0 | [Synonyms]
SC 19220
2-acetylhydrazide 10(11h)-carboxylic acid
8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid
N'-acetyl-3-chloro-6H-benzo[b][1,4]benzoxazepine-5-carbohydrazide
8-CHLORO-DIBENZ[B,F][1,4]OXAZEPINE-10[11H]-CARBOXY-(2-ACETYL)HYDRAZIDE
8-CHLORO-DIBENZ[B,F][1,4]OXAZEPINE-10(11H)-CARBOXYLIC ACID, 2-ACETYLHYDRAZIDE
8-CHLORO-DIBENZO[B,F][1,4]OXAZEPINE-10(11H)-CARBOXYLIC ACID, 2-ACETYLHYDRAZIDE
Dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide
8-Chloro-dibenzo(Z)[b,f][1,4]oxazepine-10(11H)-carboxylicacid,2-acetylhydrazide
2-Acetylhydrazide 10(11H)-carboxylic acid, 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid | [Molecular Formula]
C16H14ClN3O3 | [MDL Number]
MFCD02259329 | [MOL File]
19395-87-0.mol | [Molecular Weight]
331.75 |
| Hazard Information | Back Directory | [Uses]
SC 19220 is a selective EP1?receptor antagonist. | [Uses]
SC 19220 was used to study the role of prostaglandin E2 in oxygen-glucose deprivation-induced neurotoxicity and preconditioning-induced neuroprotection in rat cortical cultures. | [Definition]
ChEBI: N'-acetyl-3-chloro-6H-benzo[b][1,4]benzoxazepine-5-carbohydrazide is an aromatic ether. | [Biological Activity]
Selective EP 1 receptor antagonist (IC 50 = 6.7 μ M for inhibition of [ 3 H]-PGE 2 binding to EP 1 transfected COS cells). | [Biochem/physiol Actions]
SC 19220 is a competitive antagonist of prostaglandin E receptors. It competes with PGE2 in regulating vesicourethral motility and increases the bladder capacity of rats. It inhibits the contraction of smooth muscles in response to prostaglandins E2 and F2α. SC 19220 also inhibits the formation of osteoclasts induced by vitamin D3, parathyroid hormone, IL-11 and IL-6. | [storage]
Store at RT |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|