| Identification | Back Directory | [Name]
BRL 15572 HYDROCHLORIDE | [CAS]
193611-72-2 | [Synonyms]
CS-222
-15572 HCL
BRL15572HCl
BRL 15572 HYDROCHLORIDE
BRL-15572 (dihydrochloride)
BRL 15572 HYDROCHLORIDE USP/EP/BP
BRL-15572 dihydrochloride
(BRL15572
3-[4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]-1,1-DIPHENYL-2-PROPANOL HCL
3-[4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]-1,1-DIPHENYL-2-PROPANOL HYDROCHLORIDE
3-(4-(3-chlorophenyl)piperazin-1-yl)-1,1-diphenylpropan-2-ol dihydrochloride
4-(3-Chlorophenyl)-alpha-(diphenylmethyl)-1-piperazineethanol dihydrochloride | [Molecular Formula]
C25H28Cl2N2O | [MDL Number]
MFCD06804645 | [MOL File]
193611-72-2.mol | [Molecular Weight]
443.41 |
| Hazard Information | Back Directory | [Uses]
BRL 15572 Hydrochloride is an analog of BRL 15572, which is a preferential antagonist at native human 5-HT1D receptors. | [Biological Activity]
A selective h5-HT 1D antagonist, displaying 60-fold selectivity over h5-HT 1B , and exhibiting little or no affinity for a range of other receptor types. | [in vivo]
BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test[2].
BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig[3]. | [target]
5-HT1D | [IC 50]
5-HT1D Receptor | [References]
[1] price g w, burton m j, collin l j, et al. sb-216641 and brl-15572–compounds to pharmacologically discriminate h5-ht1b and h5-ht1d receptors. naunyn-schmiedeberg's archives of pharmacology, 1997, 356(3): 312-320. |
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