| Identification | Back Directory | [Name]
HUMAN RANTES | [CAS]
1927910-48-2 | [Synonyms]
CCL8
HC14
MCP-2
RHRANTES
HUMAN CCL5
MCP-2, HUMAN
HUMAN RANTES
RANTES, HUMAN
HUMAN SIS-DELTA
MCP-2 from mouse
HUMAN MCP2 (CCL8)
REC RANTES (HUMAN)
HUMAN RANTES (CCL5)
RANTES [HOMO SAPIENS]
RECOMBINANT HUMAN RANTES
RANTES, HUMAN, RECOMBINANT
Small inducible cytokine A8
Human CCL8 Protein, His Tag
Monocyte chemotactic protein 2
MONOCYTE CHEMOTACTIC PROTEIN-2 (HUMAN)
Recombinant Human CCL8/MCP-2 Protein, No Tag
Recombinant Mouse Ccl8/MCP-2 Protein, His Tag
Recombinant Human CCL8/MCP-2 Protein, His Tag
MACROPHAGE/MONOCYTE CHEMOTACTIC PROTEIN-2, HUMAN
HUMAN MCP2 (CCL8) CHEMICALLY SYNTHESIZED CHEMOKINE
HUMAN RANTES (CCL5) CHEMICALLY SYNTHESIZED CHEMOKINE
HUMAN REGULATED UPON ACTIVATION NORMAL T CELL EXPRESSED SEQUENCE
Regulated on Activation, Normal T-cell Expressed and Secreted
SMall-Inducible Cytokine A5, CCL5, T Cell-Specific Protein P228, TCP228
H-Ser-Pro-Tyr-Ser-Ser-Asp-Thr-Thr-Pro-Cys-Cys-Phe-Ala-Tyr-Ile-Ala-Arg-Pro-Leu-Pro-Arg-Ala-His-Ile-Lys-Glu-Tyr-Phe-Tyr-Thr-Ser-Gly-Lys-Cys-Ser-Asn-Pro-Ala-Val-Val-Phe-Val-Thr-Arg-Lys-Asn-Arg-Gln-Val-Cys-Ala-Asn-Pro-Glu-Lys-Lys-Trp-Val-Arg-Glu-Tyr-Ile-Asn-Ser-Leu-Glu-Met-Ser-OH | [MDL Number]
MFCD00213042 |
| Hazard Information | Back Directory | [Uses]
RANTES human has been used in following studies:
- In transmigration experiments to determine whether LFA-1 cross-linking could affect peripheral blood T lymphocytes (PBTL) migration in response to the chemokine RANTES.
- Luminol-dependent chemiluminescence assay to determine the effect of RANTES on reactive oxygen species (ROS) production by eosinophils.
| [Biological Activity]
Regulated on activationnormal T cell expressed and secreted (RANTES) is a chemoattractant towards monocytesdendritic cells (DCs)memory T cells (CD4+/CD45RO)basophilsand eosinophils. The encoded chemokine protein functions as a ligand for CCR1CCR3and CCR5.1 RANTES inhibits the action of R5 strains of HIV-1 via blocking CCR5 receptor. The In1.1C variant of RANTES gene is linked with susceptibility to HIV-1 infection and disease progression. Hencethis can be used as a potent biomarker to determine the prognosis of HIV-1 infection. |
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