| Identification | Back Directory | [Name]
GSK9311 | [CAS]
1923851-49-3 | [Synonyms]
GSK9311
GSK 9311;GSK-9311
GSK9311 >=98% (HPLC)
GSK 9311 hydrochloride
BRPF1 bromodomain inhibitor GS9311
Benzamide, N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-N-ethyl-2-methoxy- | [Molecular Formula]
C24H31N5O3 | [MOL File]
1923851-49-3.mol | [Molecular Weight]
437.53 |
| Chemical Properties | Back Directory | [Boiling point ]
625.5±55.0 °C(Predicted) | [density ]
1.204±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 30 mg/mL (68.57 mM) | [form ]
Solid | [pka]
8.82±0.40(Predicted) | [color ]
White to off-white | [optical activity]
[α]/D 90 to 100°, c =0.3 in methanol |
| Hazard Information | Back Directory | [Biological Activity]
GSK9311 is a negative control for the SGC epigenetic probe GSK6853. GSK9311 exhibits 125- and 185-fold reduced potency than its structural analog GSK6853 toward BRPF1 in cell-free and cell-based assays (pIC50 = 6.0/GSK9311 vs. 8.1/GSK6853 in ligand competition binding assay by TR-FRET; IC50 = 3.7 μM/GSK9311 vs. 20 nM/GSK6853 against NanoLuc-BRPF1 bromodomain interaction with Histone H3.3-HaloTag in HEK293 cells)and therefore serves as a good inactive control compound in BRPF1 inhibition studies employing GSK6853. For characterization details of the active probeGSK6853please visit the GSK6853 probe summary on the Structural Genomics Consortium (SGC) website.
GSK6853the active probeis available from Sigma. To learn more about and purchase GSK6853click here.
To learn about other SGC chemical probes for epigenetic targets | [storage]
Store at -20°C |
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BOC Sciences
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https://www.bocsci.com |
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DC Chemicals
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021-58447131 13564518121 |
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http://m.is0513.com/ShowSupplierProductsList927327/0.htm |
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