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ChemicalBook--->CAS DataBase List--->187887-46-3

187887-46-3

187887-46-3 Structure

187887-46-3 Structure
IdentificationBack Directory
[Name]

Triproamylin acetate
[CAS]

187887-46-3
[Synonyms]

Symlin
Triproamylin acetate
Pramlintide acetate salt
Pramlintide acetate(151126-32-8 free base)
Pramlintide acetate(151126 32 8 free base),Pramlintide acetate(151126328 free base)
[Molecular Formula]

C173H271N51O55S2
[MDL Number]

MFCD08460172
[MOL File]

187887-46-3.mol
[Molecular Weight]

4009.44
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Biochem/physiol Actions]

Pramlintide (AC0137, AC137, triPro-amylin) is a synthetic antidiabetic peptide that corresponds to human amylin (aa34-70) with proline substitutions at N25, S28 and S29 to limit the self-aggregation seen with native amylin. Pramlintide augments endogenous amylin-mediated glycemic control (blood glucose regulation) in vivo by delaying gastric emptying and inhibiting the secretion of glucagon, a catabolic hormone that opposes the effects of insulin and amylin.
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