| Identification | Back Directory | [Name]
2-(4,5-DIHYDROIMIDAZOL-2-YL)QUINOLINE HYDROCHLORIDE | [CAS]
187173-05-3 | [Synonyms]
BU 224 HYDROCHLORIDE
Quinoline, 2-(4,5-dihydro-1H-imidazol-2-yl)-
2-(4,5-DIHYDROIMIDAZOL-2-YL)QUINOLINE HYDROCHLORIDE | [Molecular Formula]
C12H11N3 | [MDL Number]
MFCD00467639 | [MOL File]
187173-05-3.mol | [Molecular Weight]
197.24 |
| Chemical Properties | Back Directory | [Boiling point ]
372.9±34.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at RT | [solubility ]
ethanol: 1.2 mg/mL | [form ]
solid | [pka]
9.87±0.40(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
BU224 is one of the two most widely studied I2 receptor ligands and have antinociceptive and antidepressant-?like activities in rodents. | [Biological Activity]
High affinity ligand for the imidazoline I 2 binding site (K i = 2.1 nM). Putative I 2 antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract. |
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