| Identification | Back Directory | [Name]
LY 344864 | [CAS]
186544-26-3 | [Synonyms]
CS-660
Y344864
LY 344864
LY344864 HCL
LY344864;LY-344864
LY 344864 hydrochloride
(R)-N-[3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide
Benzamide, N-[(3R)-3-(dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluoro-
(R)-N-(3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)-4-fluorobenzamide hydrochloride
N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamidehydrochloride | [Molecular Formula]
C21H22FN3O | [MDL Number]
MFCD07772184 | [MOL File]
186544-26-3.mol | [Molecular Weight]
351.42 |
| Chemical Properties | Back Directory | [Boiling point ]
471.9±45.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
DMSO : ≥ 350 mg/mL (995.96 mM) | [form ]
Powder | [pka]
14.12±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
LY-344864 Hydrochloride is used as a selective 5-HTIF receptor agonist. | [Biological Activity]
Potent, selective 5-HT 1F receptor agonist (EC 50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (K i values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μ M for 5-HT 1F , 5-HT 1A , 5-HT 1B , 5-HT 1D , 5-HT 1E , 5-HT 2B , 5-HT 2C , 5-HT 2A and 5-HT 7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration. |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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