| Identification | Back Directory | [Name]
TAK-828F | [CAS]
1854901-94-2 | [Synonyms]
TAK-828F
Cyclobutaneacetic acid, 3-[[(5R)-5-[[(7-fluoro-2,3-dihydro-1,1-dimethyl-1H-inden-5-yl)amino]carbonyl]-7,8-dihydro-2-methoxy-1,6-naphthyridin-6(5H)-yl]carbonyl]-, cis- | [Molecular Formula]
C28H32FN3O5 | [MDL Number]
MFCD31813652 | [MOL File]
1854901-94-2.mol | [Molecular Weight]
509.57 |
| Hazard Information | Back Directory | [Description]
TAK-828F is a potent and selective orally available RORγt inverse agonist. TAK-828F showed Binding IC50 = 1.9 nM; Reporter gene IC50=6.1 nM; logD=3.53; LLE (reporter gene)=4.68. TAK-828F inhibited IL-17 production from mouse splenocytes and human peripheral blood mononuclear cells dose-dependently at concentrations of 0.01-10?μM without affecting the production of IFN-γ. TAK-828F may provide a novel therapeutic option to treat immune diseases by inhibiting Th17 and Th1/17 cells' differentiation and improving imbalance between Th17 and Treg cells. |
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DC Chemicals
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