| Identification | Back Directory | [Name]
N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan | [CAS]
185351-19-3 | [Synonyms]
NQTrp
NQTrp >=98% (HPLC)
1,4-Naphthoquinon-2-yl-l-tryptophan
N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan
L-Tryptophan, N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)- | [Molecular Formula]
C21H16N2O4 | [MDL Number]
MFCD21496345 | [MOL File]
185351-19-3.mol | [Molecular Weight]
360.36 |
| Chemical Properties | Back Directory | [Melting point ]
208.0-211.0 °C | [Boiling point ]
658.9±55.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [pka]
3.89±0.10(Predicted) | [color ]
orange to dark orange-red |
| Hazard Information | Back Directory | [Description]
NQTrp is an inhibitor of Alzheimer’s disease-associated amyloid β (Aβ) oligomerization and fibrillization (IC50 = 50 nM for formation of fibrils from Aβ1-42). It has been shown to reduce the cytotoxic effect of Aβ oligomers in a cultured neuronal cell line. | [Uses]
NQTrp is a inhibitor of Aβ1-42 aggregation, altering Aβ self-assembly and reducing toxicity. | [References]
[1]. scherzer-attali r, pellarin r, convertino m, et al. complete phenotypic recovery of an alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor. plos one. 2010 jun 14;5(6):e11101.
[2]. zhang t, xu w, mu y, et al. atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-l-tryptophan inhibitor on alzheimer's aβ1-42 dimer in terms of aggregation and toxicity. acs chem neurosci. 2014 feb 19;5(2):148-59. |
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