| Identification | Back Directory | [Name]
ditazole | [CAS]
18471-20-0 | [Synonyms]
S-222
ditazol
Apt-574
ditazole
Agerophas
Diethamphenazole
2,2'-[(4,5-Diphenyl-2-oxazolyl)imino]bisethanol
2-[(4,5-diphenyl-1,3-oxazol-2-yl)-(2-hydroxyethyl)amino]ethanol | [EINECS(EC#)]
242-353-5 | [Molecular Formula]
C19H20N2O3 | [MDL Number]
MFCD00866073 | [MOL File]
18471-20-0.mol | [Molecular Weight]
324.37 |
| Chemical Properties | Back Directory | [Melting point ]
100-101°C | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Originator]
Ageroplas,Serona,Italy,1973 | [Uses]
Ditazole is a weak anti-inflammatory drug and a novel inhibitor of platelet aggregation. | [Definition]
ChEBI: Ditazole is a member of 1,3-oxazoles. | [Manufacturing Process]
A solution of 5.1 grams 2-chloro-4,5-diphenyl-oxazole, 6.3 grams
diethanolamine and 50 ml absolute ethanol was refluxed for 4 hours. The
solvent was stripped at 1 mm and the oily residue was added at 60°C to 100
ml 50% ethanol; by cooling the hydro-alcoholic solution, 4.5 grams of 2-bis(β-
hydroxyethyl)amino-4,5-diphenyl-oxazole was obtained (yield, 69.5%). The
product crystallized from ethyl ether + petroleum ether, with a MP of 96 to
98°C. | [Therapeutic Function]
Antiinflammatory |
|
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