| Identification | Back Directory | [Name]
6-(5-carboxy-5-methyl-hexoxy)-2,2-dimethyl-hexanoic acid | [CAS]
183293-82-5 | [Synonyms]
PD-72953
gemcabene
Hexanoic acid, 6,6'-oxybis[2,2-dimethyl-
6-(5-carboxy-5-methyl-hexoxy)-2,2-dimethyl-hexanoic acid
6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethyl-hexanoic acid | [Molecular Formula]
C16H30O5 | [MDL Number]
MFCD00951832 | [MOL File]
183293-82-5.mol | [Molecular Weight]
302.41 |
| Chemical Properties | Back Directory | [Melting point ]
49-51 °C | [Boiling point ]
453.6±30.0 °C(Predicted) | [density ]
1.048±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 125 mg/mL (413.35 mM) | [form ]
Solid | [pka]
4.52±0.45(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Atherosclerosis therapy; treatment of lipoprotein disorders. | [Biological Activity]
Gemcabene is an orally available lipid-regulating compound th at induces both a cholesterol and triglyceride reduction by a mechanism of action not linked to agonist or antagonist activity on the PPAR-α receptors. Gemcabene down-regulates apoC-III expression. Gemcabene is primarily metabolized (glucuronidation) by UDP-glucuronosyltransferase2B7 (UGT2B7). Thusis often used as a UGT2B7 substrate. |
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