| Identification | Back Directory | [Name]
Urea, N-[2-chloro-7-[(1R,2R)-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-N'-[5-chloro-6-(2H-1,2,3-triazol-2-yl)-3-pyridinyl]- | [CAS]
1832578-30-9 | [Synonyms]
MLT-748
Urea, N-[2-chloro-7-[(1R,2R)-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-N'-[5-chloro-6-(2H-1,2,3-triazol-2-yl)-3-pyridinyl]- | [Molecular Formula]
C19H19Cl2N9O3 | [MDL Number]
MFCD31813802 | [MOL File]
1832578-30-9.mol | [Molecular Weight]
492.32 |
| Chemical Properties | Back Directory | [density ]
1.61±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 200 mg/mL (406.24 mM; Need ultrasonic) | [form ]
Solid | [pka]
7.78±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MLT-748 is a potent, selective and allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM[1]. | [References]
[1] Quancard J, et al. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat Chem Biol. 2019 Mar;15(3):304-313. DOI:10.1038/s41589-018-0222-1 |
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DC Chemicals
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