| Chemical Properties | Back Directory | [Boiling point ]
703.9±70.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 1 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml | [form ]
A crystalline solid | [pka]
3.53±0.12(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC50 value of 0.57 μM.1 JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC50 = 8.5 μM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2.1 JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysates and intact cells.1 | [storage]
Store at -20°C | [References]
1. Parsons, W.H., Kolar, M.J., Kamat, S.S., et al. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs Nat. Chem. Biol. 12(5),367-372(2016). |
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