| Identification | Back Directory | [Name]
LY 334370 HYDROCHLORIDE | [CAS]
182563-08-2 | [Synonyms]
Y334370
LY 334370
Y 334370 HCL
LY 334370 HCL
LY 334370 HYDROCHLORIDE
LY334370;LY-334370;LY 334370
LY-334370 hydrochloride hydrate
4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benazmide
4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-indol-5-yl]-benzamide
BenzaMide, 4-fluoro-N-[3-(1-Methyl-4-piperidinyl)-1H-indol-5-yl]-
4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamidehydrochloride
4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benzamide hydrochloride
4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benazmide hydrochloride
4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride hydrate | [Molecular Formula]
C21H22FN3O | [MDL Number]
MFCD11519957 | [MOL File]
182563-08-2.mol | [Molecular Weight]
351.42 |
| Chemical Properties | Back Directory | [Boiling point ]
479.1±45.0 °C(Predicted) | [density ]
1.267±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
H2O: ≥5mg/mL (warmed) | [form ]
powder | [pka]
13.98±0.43(Predicted) | [color ]
white to tan |
| Hazard Information | Back Directory | [Uses]
LY 334370 Hydrochloride is a 5-HT1f receptor agoniist used potentially in the treatment of migranes. | [Biological Activity]
Selective 5-HT 1F receptor agonist (K i values are 1.87, 16.4, > 100 (IC 50 ), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC 50 ) and 3250 nM for 5-HT 1F , 5-HT 1A , 5-HT 4 , 5-HT 1E , 5-HT 1B , 5-HT 1D , 5-HT 2B , 5-HT 2A , 5-HT 7 , 5-HT 6 and 5-HT 2C receptors respectively). Displays antimigraine effects. | [in vivo]
Following intravenous administration of LY334370 at 3 mg/kg (n=3) or 10 mg/kg (n=6) electrical stimulation evokes an increase in dural blood vessel diameter of 135±6% and 106±11%, respectively, which is not significantly different from the respective control values. LY334370 has no effect on dural blood vessel diameter per se, since the actual dural blood vessel diameter is 43±4 arbitrary units before drug and 43±4 arbitrary units 15 min after injection of LY334370 (10 mg/kg)[1]. | [IC 50]
5-HT1F Receptor: 1.6 nM (Ki) | [storage]
Store at -20°C |
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