| Identification | Back Directory | [Name]
TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE | [CAS]
182344-70-3 | [Synonyms]
N-Boc-5-bromoindole
1-BOC-5-bromoindole
1-Boc-5-bromo-1H-indole
N-Boc-5-bromoindole 13C6
5-Bromo-1-tert-butoxycarbonylindole
5-Bromo-1-(t-Butoxycarbonyl)-1H-indole
TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE
5-BROMO-1-(TERT-BUTOXYCARBONYL)-1H-INDOLE
TERT-BUTYL 5-BROMO-1H-INDOLE-1-CARBOXYLATE
5-bromo-1-indolecarboxylic acid tert-butyl ester
1H-Indole-1-carboxylic acid, 5-bromo-, 1,1-dimethylethyl ester | [Molecular Formula]
C13H14BrNO2 | [MDL Number]
MFCD02090067 | [MOL File]
182344-70-3.mol | [Molecular Weight]
296.16 |
| Chemical Properties | Back Directory | [Melting point ]
56-57 °C(lit.) | [Boiling point ]
367.9±34.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
N-Boc-5-bromoindole is formed as an intermediate for the synthesis of di-Boc-protected 5-aminoindole via a Buchwald-Hartwig amination with tBu-carbamate followed by regioselective bromination[1]. | [General Description]
N-Boc-5-bromoindole can undergo Sonogashira coupling reaction with N,N-diisopropylprop-2-ynylamine to afford the corresponding propargylic diisopropylamine. N-Boc-5-bromoindole is formed as an intermediate during the synthesis of 2-(5-substituted-1H-indol-3-yl)-N-hydroxyacetamide derivatives. | [References]
[1] Christoffer Bengtsson, et al. Rapid Construction of a Chloromethyl-Substituted Duocarmycin-like Prodrug. Molecules. 2023 Jun 16;28(12):4818. DOI:10.3390/molecules28124818 |
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Energy Chemical
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