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ChemicalBook--->CAS DataBase List--->1821280-29-8

1821280-29-8

1821280-29-8 Structure

1821280-29-8 Structure
IdentificationBack Directory
[Name]

SBI-0640756
[CAS]

1821280-29-8
[Synonyms]

SBI756
SBI-756
CS-2838
SBI 756
SBI-0640756
SBI-0640756;SBI 0640756;SBI0640756;SBI 756;SBI756;SBI-756
(E)-6-chloro-3-(3-(5-fluoropyridin-3-yl)acryloyl)-4-phenylquinolin-2(1H)-one
2(1H)-Quinolinone,6-chloro-3-[(2E)-3-(5-fluoro-3-pyridinyl)-1-oxo-2-propen-1-yl]-4-phenyl-
Chemical PropertiesBack Directory
[storage temp. ]

Inert atmosphere,2-8°C
[solubility ]

DMSO : ≥ 26 mg/mL (64.23 mM)
[form ]

Solid
[color ]

Light yellow to yellow
Spectrum DetailBack Directory
[Spectrum Detail]

SBI-0640756(1821280-29-8)1HNMR
Hazard InformationBack Directory
[Biological Activity]

SBI-0640756 is a potent inhibitor of eIF4G1 th at disrupts the eIF4F complex assembly independently of mTOR. SBI-0640756 potently inhibits growth of BRAF-resistant and BRAF-independent melanomas including NRAS- and NF1-mutant melanomas. SBI-0640756 exhibits low toxicity against nontransformed fibroblasts. SBI-0640756 also suppressed AKT and NF-kB signaling.
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