| Identification | Back Directory | [Name]
Cyclohexanol, 4-[5-[4-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)methyl]phenyl]-2-[[(1S)-1-methylbutyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans- | [CAS]
1818234-19-3 | [Synonyms]
UNC 4203
Cyclohexanol, 4-[5-[4-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)methyl]phenyl]-2-[[(1S)-1-methylbutyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans- | [Molecular Formula]
C30H44N6O | [MOL File]
1818234-19-3.mol | [Molecular Weight]
504.71 |
| Chemical Properties | Back Directory | [Boiling point ]
682.0±65.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
14.63±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
UNC4203 is a potent and selective MERTK Inhibitor. UNC4203 showed IC50 MerTK=2.4 nM (Ki=0.42 nM); IC50 Axl = 80 nM (Ki=40.22 nM); IC50 Tyro3 = 9.1 nM (Ki=3.87 nM). IC50 FLT3 = 39 nM *Ki=16.14 nM). T1/2 = 3.0 h; %F=15. UNC4203 may be a potential candidate for cancer treatment. |
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