| Identification | Back Directory | [Name]
1H-Pyrazolo[4,3-c]pyridine-3-carboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N-[3-[(1R)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7R)- | [CAS]
1816272-19-1 | [Synonyms]
1H-Pyrazolo[4,3-c]pyridine-3-carboxamide, 1-[(4-fluorophenyl)methyl]-4,5,6,7-tetrahydro-N-[3-[(1R)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-, (7R)- | [Molecular Formula]
C28H28FN5O3 | [MOL File]
1816272-19-1.mol | [Molecular Weight]
501.55 |
| Chemical Properties | Back Directory | [Boiling point ]
704.2±60.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
12.26±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
WT IDH1 Inhibitor 2 (Compound 3) is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. WT IDH1 Inhibitor 2 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity[1].
WT IDH1 Inhibitor 2 (0.1~3 μM; 5 hours; A-498 cells) dose dependent decreases in reductive glutaminolysis[1]. | [References]
[1]. Jakob CG, U et al. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J Med Chem. 2018;61(15):6647-6657. |
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