| Identification | Back Directory | [Name]
NETROPSIN DIHYDROCHLORIDE HYDRATE | [CAS]
18133-22-7 | [Synonyms]
Nsc275885
netropsin2HClhydrate
Netropsin hydrate dihydrochloride
NETROPSIN DIHYDROCHLORIDE HYDRATE 96%
Netropsin, 2 HCl, Streptomycesnetropsis (1.24791)
1H-Pyrrole-2-carboxamide, 4-(aminoiminomethyl)aminoacetylamino-N-5-(3-amino-3-iminopropyl)aminocarbonyl-1-methyl-1H-pyrrol-3-yl-1-methyl-, dihydrochloride | [Molecular Formula]
C18H26N10O32HCl | [MDL Number]
MFCD00144883 | [MOL File]
18133-22-7.mol | [Molecular Weight]
466.93 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble1mg/mL | [form ]
powder | [color ]
faint yellow | [biological source]
Streptomyces netropsis | [Water Solubility ]
H2O: 1mg/mL |
| Hazard Information | Back Directory | [Uses]
Netropsin Dihydrochloride is DNA minor groove binding ligand. | [Biochem/physiol Actions]
Netropsin is an unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin disrupts the cell cycle, prolonging G and arresting in G. |
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Sigma-Aldrich
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