| Identification | Back Directory | [Name]
Biotin-PEG6-Mal | [CAS]
1808990-66-0 | [Synonyms]
Biotin-PEG6-Mal
Biotin-PEG6-amido-Mal
(+)-Biotin-PEG6-NH-Mal
(+)-Biotin-PEG6-NH-Mal
(+)-Biotin-PEG6-Maleimide
(+)-Biotin-PEG6-Maleimide
N-Biotinyl-N'-(3-maleimidopropionyl)-3,6,9,12,15,18-hexaoxaicosane-1,20-diamine
N-[2-[2-[2-[2-[2-[2-[2-[(3-Maleimidopropionyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]biotinamide
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[24-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-22-oxo-3,6,9,12,15,18-hexaoxa-21-azatetracos-1-yl]hexahydro-2-oxo-, (3aS,4S,6aR)- | [Molecular Formula]
C31H51N5O11S | [MDL Number]
MFCD28015769 | [MOL File]
1808990-66-0.mol | [Molecular Weight]
701.83 |
| Chemical Properties | Back Directory | [Boiling point ]
944.7±65.0 °C(Predicted) | [density ]
1.229±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DCM | [form ]
powder to crystal | [pka]
13.90±0.40(Predicted) | [color ]
White to Light yellow |
| Hazard Information | Back Directory | [Description]
Biotin-PEG6-Mal is a maleimide biotinylation linker that can react with sulfhydryl groups (at pH 6.5-7.5) specifically to form a thioether linkage. The hydrophilic PEG spacer increases aqueous solubility of the molecules conjugated to the biotin compound. It also helps to minimize steric hindrance involved with the binding to avidin molecules. | [Uses]
Biotin-PEG6-Mal is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329 |
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TCI Europe
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320-37350700 |
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https://www.tcichemicals.com/de/de/index.html |
| Company Name: |
TCI AMERICA
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800-4238616 |
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https://www.tcichemicals.com/en/us/index.html |
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