| Identification | Back Directory | [Name]
Fluorescein-PEG3-Amine | [CAS]
1807539-04-3 | [Synonyms]
5-FITC-PEG3-Amine
Fluorescein-PEG3-NH2
Fluorescein-PEG3-Amine
5,8,11-Trioxa-2-azatridecanethioamide, 13-amino-N-(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)- | [Molecular Formula]
C29H31N3O8S | [MDL Number]
MFCD23726633 | [MOL File]
1807539-04-3.mol | [Molecular Weight]
581.64 |
| Chemical Properties | Back Directory | [Boiling point ]
807.4±75.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DMF, DCM | [pka]
9.33±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
Fluorescein-PEG3-Amine is a fluorescein dye with excitation/emmission maximum 494/517 nm containing a free amine group, which can be reactive with cabroxylic acid, activated NHS ester, carbonyl (ketone, aldehyde) etc. The hydophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding. | [Uses]
Fluorescein-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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Alfa Chemistry
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https://www.alfa-chemistry.com |
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