| Hazard Information | Back Directory | [in vivo]
Samuraciclib (ICEC0942; 100 mg/kg; oral gavage; daily; for 14 days; female nu/nu-BALB/c athymic nude mice) treatment inhibits tumor growth by 60% at day 14, and is accompanied by highly significant reductions in PolII Ser2 and Ser5 phosphorylation in PBMCs and in tumors[1].
The combination of Samuraciclib (ICEC0942) and ICI 47699 treatment shows complete growth arrest of estrogen receptor (ER)-positive tumor xenografts[1]. | Animal Model: | Female nu/nu-BALB/c athymic nude mice (7-week old) with MCF7 cells[1]. | | Dosage: | 100 mg/kg | | Administration: | Oral gavage; daily; for 14 days | | Result: | At day 14, tumor growth was inhibited by 60%. |
| [IC 50]
CDK7/CycH/MAT1: 41 nM (IC50); CDK2/cycE1: 578 nM (IC50); CDK1: 1.8 μM (IC50); CDK4: 49 μM (IC50); CDK5: 9.4 μM (IC50); CDK6: 34 μM (IC50); CDK9: 1.2 μM (IC50) |
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