| Identification | Back Directory | [Name]
Avibactam Impurity 46 | [CAS]
1804915-68-1 | [Synonyms]
WCK4234
Avibactam Impurity 46
sodium (2R,5R)-2-cyano-7-oxo-6-azabicyclo[3.2.1]octan-6-yl sulfate | [Molecular Formula]
C7H10N3NaO5S | [MOL File]
1804915-68-1.mol | [Molecular Weight]
271.22 |
| Hazard Information | Back Directory | [Biological Activity]
WCK-4234 is a potent β-lactamase inhibitor. WCK-4234 inhibits class A, C, and D β-lactamases activity. WCK-4234 lacks direct antibacterial activity. WCK-4234 potentiates imipenem and meropenem against Enterobacteriaceae with OXA-48/OXA-181 or KPC enzymes, or with combinations of impermeability and AmpC or ESBL activity. WCK-4234 distinctively overcomes resistance mediated by OXA-type carbapenemases[1][2]. | [storage]
-20°C, away from moisture | [References]
[1]. Iregui A, et al. Activity of Meropenem with a Novel Broader-Spectrum β-Lactamase Inhibitor, WCK 4234, against Gram-Negative Pathogens Endemic to New York City. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01666-19. [2]. Mushtaq S, et al. WCK 4234, a novel diazabicyclooctane potentiating carbapenems against Enterobacteriaceae, Pseudomonas and Acinetobacter with class A, C and D β-lactamases. J Antimicrob Chemother. 2017 Jun 1;72(6):1688-1695. |
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