| Identification | Back Directory | [Name]
ETIROXATE | [CAS]
17365-01-4 | [Synonyms]
CG-63
CG-635
ETIROXATE
DL-a-Methyl-thyroxine Ethyl Ester
DL-α-Methyl-thyroxine Ethyl Ester
O-(4-Hydroxy-3,5-diiodo-phenyl)-3,5-diiodo-α-methyl-DL-tyrosine Ethyl Ester
O-(4-Hydroxy-3,5-diiodo-phenyl)-3,5-diiodo-a-methyl-DL-tyrosine Ethyl Ester
(±)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-2-methylpropionic acid ethyl ester | [Molecular Formula]
C18H17I4NO4 | [MDL Number]
MFCD00865750 | [MOL File]
17365-01-4.mol | [Molecular Weight]
818.935 |
| Hazard Information | Back Directory | [Chemical Properties]
Tan Solid | [Uses]
Derivative of thyroxine. Antilipemic | [Originator]
Skleronorm,Gruenenthal,W. Germany,1977 | [Definition]
ChEBI: Etiroxate is an aromatic ether. | [Manufacturing Process]
7.91 g of α-methyl thyroxine are suspended in 150 cc of ethanol. While
heating, the solution is saturated with dry hydrogen chloride. Thereafter, the
solvent is distilled off at reduced pressure. The residue is dissolved in a
mixture of ethanol and water (1:1). Adding a 5% solution of sodium hydrogen
carbonate in water, the ethyl ester of α-methyl thyroxine precipitates; melting
point: 156°C to 157°C after recrystallization from ethanol. The yield is 6.05 g,
i.e., 74% of the theoretical yield. | [Therapeutic Function]
Antihyperlipoproteinemic |
|
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