| Identification | Back Directory | [Name]
Ilaprazole sodium | [CAS]
172152-50-0 | [Synonyms]
IY-81149 sodium
Ilaprazole sodium
Sodium ilaprazole
Ilaprazole sodium USP/EP/BP | [Molecular Formula]
C19H19N4NaO2S | [MDL Number]
MFCD30719460 | [MOL File]
172152-50-0.mol | [Molecular Weight]
390.44 |
| Hazard Information | Back Directory | [Uses]
After oral administration, Ilaprazole sodium selectively enters the gastric parietal cells and is converted into an active metabolite of sulfenamide, which interacts with the sulfhydryl group on the H+/K+-ATPase to form a covalent combination of disulfide bonds, irreversibly inhibiting H+/K+- ATPase, which inhibits gastric acid secretion. | [in vitro]
On cumulation of 14C-aminopyrine in histamine stimulated parietal cells, the IC 50 of Ilaprazole (IY-81149) sodium is 9 nM. | [target]
| Target | Value | Proton pump
() | | H(+) /K(+)-ATPase
(in rabbit parietal cell preparation) | 6 μM |
| [storage]
4°C, protect from light |
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