| Identification | Back Directory | [Name]
Guvacoline Hydrobromide | [CAS]
17210-51-4 | [Synonyms]
1,2,5,6-Tetrahydro-3-pyridinecarboxylic Acid Methyl Ester HydrobroMide
1,2,5,6-tetrahydro-3-pyridinecarboxylic acid, methyl ester, monohydrobromide | [Molecular Formula]
C7H12BrNO2 | [MDL Number]
MFCD02683335 | [MOL File]
17210-51-4.mol | [Molecular Weight]
222.08 |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline Solid | [Uses]
A muscarinic receptor used as nootropic agent. | [Biological Activity]
guvacoline is a kind of natural alkaloid which is found in areca nuts that is related to the nootropic, arecoline. guvacoline can function as a full agonist of atrial and ileal muscarinic receptors.in vitro: in human buccal epithelial cells, guvacoline could significantly decrease the colony-formation efficiency in a dose dependent manner, with the ic50 value of 2.1 mm. besides, guvacoline could also dose-dependently reduce the amount of total free low-molecular-weight thiols (0.88 mm guvacoline caused 25% decrease) and increase the number of single strand breaks [1]. | [target]
atrial and ileal muscarinic receptors | [IC 50]
2.1 mm for growth inhibition of human buccal epithelial cells | [References]
[1] k. sundqvist, y. liu, j. nair, et al. cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. cancer research 49(19), 5294-5298 (1989). |
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