| Identification | Back Directory | [Name]
Nampt-IN-1 | [CAS]
1698878-14-6 | [Synonyms]
Nampt-IN-1
LSN3154567
Nampt inhibitor 1
LSN3154567 (Nampt-IN-1)
LSN 3154567;LSN-3154567;LSN3154567
2-hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-
2-Hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-1-propanesulfonamide
2-hydroxy-2-methyl-N-(2-(2-(pyridin-3-yloxy)acetyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)propane-1-sulfonamide
1-Propanesulfonamide, 2-hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]- | [Molecular Formula]
C20H25N3O5S | [MDL Number]
MFCD28963946 | [MOL File]
1698878-14-6.mol | [Molecular Weight]
419.49 |
| Chemical Properties | Back Directory | [Boiling point ]
659.9±65.0 °C(Predicted) | [density ]
1.363±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: Soluble | [form ]
powder | [pka]
8.67±0.20(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
Nampt-IN-1 is a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt; IC50 = 3.1 nM). It is selective for Nampt over a panel of greater than 100 human kinases at 1 μM. Nampt-IN-1 inhibits NAD+ formation in and proliferation of HCT116 cells (IC50s = 1.8 and 8.9 nM, respectively). It inhibits cell growth in a panel of cancer cell lines (IC50s = <0.2-2 μM). Nampt-IN-1 inhibits NAD+ formation in an A2780 ovarian carcinoma mouse xenograft model (ED50 = 2 mg/kg). | [Uses]
Nampt-IN-1 functions as a co-drug. Nampt-IN-1 is a potent and selective NAMPT inhibitor. | [Biochem/physiol Actions]
LSN3154567 might be useful in developing a novel cancer therapeutic. |
|
|