| Identification | Back Directory | [Name]
AIDA | [CAS]
168560-79-0 | [Synonyms]
AIDA
UPF 523
AIDA,UPF-523
(R,S)-1-Aminoindane-1,5
(RS)-1-AMINOINDAN-1,5-DICARBOXYLIC ACID
(+/-)-1-AMINOINDAN-1,5-DICARBOXYLIC ACID
(R,S)-1-Aminoindane-1,5-dicarboxylicacid
(+/-)-1-AMINOINDANE-1,5-DICARBOXYLIC ACID
(±)-1-Aminoindan-1,5-dicarboxylic acid,95%
(#1)-1-Aminoindan-1,5-dicarboxylic acidAIDA
1-AMINOINDAN-1,5-DICARBOXYLIC ACID,UPF 5 23
(§1)-1-Aminoindan-1,5-dicarboxylic acid, 95%
1-AMINO-2,3-DIHYDRO-1H-INDENE-1,5-DICARBOXYLIC ACID
1-Amino-2,3-dihydro-1H-indene-1,5-dicarboxylic acid1-Aminoindan-1, 5-dicarboxylic acid
1-Amino-2,3-dihydro-1H-indene-1,5-dicarboxylic acid, 1-Aminoindan-1, 5-dicarboxylic acid, UPF 523 | [Molecular Formula]
C11H11NO4 | [MDL Number]
MFCD00672638 | [MOL File]
168560-79-0.mol | [Molecular Weight]
221.21 |
| Chemical Properties | Back Directory | [Appearance]
white to off-white powder | [Boiling point ]
362.26°C (rough estimate) | [density ]
1.2818 (rough estimate) | [refractive index ]
1.5200 (estimate) | [storage temp. ]
0-6°C | [solubility ]
DMSO: 2 mg/mL
| [form ]
solid
| [color ]
white
|
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white powder | [Biological Activity]
A relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu 1a ), having no effect on group II (mGlu 2 ) or group III (mGlu 4 ) receptors expressed individually in baby hamster kidney cells. Has no effect on ionotropic glutamate receptors. Centrally active following systemic administration in vivo . | [Uses]
AIDA is a potent and selective group I mGluR agonist. | [in vivo]
UPF-523 (0.18 mg/kg; i.p.; 0.5 ml per 100 g) results in a final concentration of 100–150 mM which is below an IC50 of 214 mM[1]. | Animal Model: | Naive male hooded Lister rats (320–350 g)[1] | | Dosage: | 0.18 mg/kg | | Administration: | I.p.; 0.5 ml per 100 g | | Result: | Showed no gross motor abnormalities and normal righting reflexes.
|
| [IC 50]
mGluR1a: 214 μM (IC50) | [storage]
Store at RT |
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