| Identification | Back Directory | [Name]
LIXIVAPTAN | [CAS]
168079-32-1 | [Synonyms]
CS-780
VPA 985
LIXIVAPTAN
Lixivaptan (VPA-985)
VPA985;LIXIVAPTAN (VPA 985)
N-[3-Chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide
N-[3-Chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide
BenzaMide,N-[3-chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-Methyl-
N-[3-chloro-4-(6,11-dihydropyrrolo[2,1-c][1,4]benzodiazepine-5-carbonyl)phenyl]-5-fluoro-2-methyl-benzamide
N-(3-Chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyl)phenyl)-5-fluoro-2-methylbenzamide
N-[3-chloro-4-(6,11-dihydropyrrolo[2,1-c][1,4]benzodiazepine-5-carbonyl)phenyl]-5-fluoro-2-methylbenzamide
or
Lixivaptan | [Molecular Formula]
C27H21ClFN3O2 | [MDL Number]
MFCD00937905 | [MOL File]
168079-32-1.mol | [Molecular Weight]
473.933 |
| Chemical Properties | Back Directory | [Melting point ]
>114°C (dec.) | [Boiling point ]
626.5±55.0 °C(Predicted) | [density ]
1.32 | [storage temp. ]
room temp | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [pka]
11.86±0.70(Predicted) | [color ]
white to beige | [InChIKey]
PPHTXRNHTVLQED-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Uses]
Lixivaptan is a drug used in the treatment and prevention of cardiovascular diseases.
| [Biological Activity]
Arginine vasopressin (AVP) plays an important part in circulatory and water homoeostasis and is important in renal hemodynamic alterationswater retentionand cardiac remodeling in congestive heart failure (CHF). Lixivaptan is an AVP V2-receptor selective antagonist th at increases water excretion and normalizes serum sodium levels. Lixivaptan has been in clinical trials for hyponatremia associated with heart failure. | [storage]
4°C, protect from light |
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