| Identification | Back Directory | [Name]
Z-ARG-LEU-ARG-GLY-GLY-AMC | [CAS]
167698-69-3 | [Synonyms]
Z-RLRGG-AMC
Z-ARG-LEU-ARG-GLY-GLY-AMC
Z-Arg-Leu-Arg-Gly-Gly-AMC (I-1690.0025)
Glycinamide, N2-[(phenylmethoxy)carbonyl]-L-arginyl-L-leucyl-L-arginylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- | [Molecular Formula]
C40H56N12O9 | [MDL Number]
MFCD00798774 | [MOL File]
167698-69-3.mol | [Molecular Weight]
848.95 |
| Hazard Information | Back Directory | [Uses]
Z-Arg-Leu-Arg-Gly-Gly-AMC is a peptide substrate of SARS-CoV PLpro[1]. | [Biological Activity]
Z-RLRGG-AMC is a fluorogenic substrate for the MERS-CoV SARS-CoVSARS-CoV-2 papain-like protease (PLpros)deubiquitinating enzyme isopeptidase T (IPaseT) and other ubiquitin C-terminal hydrolaseswhich consists of the Ub and ISG15 C-terminal sequences. Z-RLRGG-AMC excitation wavelength is 340 nmand emission wavelength is 460 nm. | [References]
[1] Schalk F, et, al. GNPS-guided discovery of xylacremolide C and D, evaluation of their putative biosynthetic origin and bioactivity studies of xylacremolide A and B. RSC Adv. 2021 May 24;11(31):18748-18756. DOI:10.1039/d1ra00997d |
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