| Identification | Back Directory | [Name]
AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE | [CAS]
167114-91-2 | [Synonyms]
ALP
ILC
CCL27
ESKINE
Skinkine
Alk Phos
FLJ10774
CTACK HUMAN
DKFZp434C116
KKALRRQEAVDAL
ALS9 AUTOCAMTIDE 2
(ALA9)-AUTOCAMTIDE-2
N-acetyltransferase 10
CTACK (CCL27) from mouse
(Ala9)-AutocaMtide-2, AIP
Anti-NAT10 antibody produced in goat
CUTANEOUS T CELL-ATTRACTING CHEMOKINE
Cuteaneous T-cell Attracting Chemokine
AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE
LYS-LYS-ALA-LEU-ARG-ARG-GLN-GLU-ALA-VAL-ASP-ALA-LEU
Anti-NAT10 (N-terminal) antibody produced in rabbit
H-LYS-LYS-ALA-LEU-ARG-ARG-GLN-GLU-ALA-VAL-ASP-ALA-LEU-OH
ALP, Cutaneous T cell-attracting Chemokine, ESkine, ILC
[Ala9] Autocamtide 2: Autocamtide-2-Related Inhibitory Peptide
Anti-Cat IgG (H+L)-Alkaline Phosphatase antibody produced in goat
Anti-Pig IgG (H+L)-Alkaline Phosphatase antibody produced in goat
Anti-Dog IgG (H+L)-Alkaline Phosphatase antibody produced in goat
Anti-Rat IgG (H+L)-Alkaline Phosphatase antibody produced in sheep
Anti-Horse IgG (H+L)-Alkaline Phosphatase antibody produced in goat
Anti-Cat IgG (H+L)-Alkaline Phosphatase antibody produced in rabbit
Anti-Cat IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat
Anti-Rat IgG (H+L)-Alkaline Phosphatase antibody produced in donkey
Anti-Swine IgG (H+L)-Alkaline Phosphatase antibody produced in goat
Anti-Donkey IgG (H+L)-Alkaline Phosphatase antibody produced in goat
Anti-Human IgG (H+L)-Alkaline Phosphatase antibody produced in sheep
Anti-Mouse IgG (H+L)-Alkaline Phosphatase antibody produced in sheep
Anti-Rat IgG (H+L)-Alkaline Phosphatase antibody produced in chicken
Anti-goat IgG (H+L)-Alkaline Phosphatase antibody produced in donkey
Anti-Rat IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
Anti-Porcine IgG (H+L)-Alkaline Phosphatase antibody produced in goat
Anti-Cat IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
Anti-goat IgG (H+L)-Alkaline Phosphatase antibody produced in chicken
Anti-Mouse IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat
Anti-Horse IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat
Anti-Mouse IgG (H+L)-Alkaline Phosphatase antibody produced in rabbit
Anti-Dog IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
Anti-Horse IgG (H+L)-Alkaline Phosphatase antibody produced in rabbit
Anti-Chicken IgG (H+L)-Alkaline Phosphatase antibody produced in goat
Anti-HAMSTER IgG (H+L)-Alkaline Phosphatase antibody produced in goat
Anti-Human IgG (H+L)-Alkaline Phosphatase antibody produced in donkey
Anti-Pig IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
Anti-Rabbit IgG (H+L)-Alkaline Phosphatase antibody produced in sheep
Anti-Mouse IgG (H+L)-Alkaline Phosphatase antibody produced in donkey
Anti-Human IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat
Anti-Rabbit IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat
Anti-Human IgG (H+L)-Alkaline Phosphatase antibody produced in chicken
Anti-Goat IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
Anti-Rabbit IgG (H+L)-Alkaline Phosphatase antibody produced in donkey
Anti-Mouse IgG (H+L)-Alkaline Phosphatase antibody produced in chicken
Anti-Bovine IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat
Anti-Donkey IgG (H+L)-Alkaline Phosphatase antibody produced in rabbit
Anti-Human IgM (Fc5μ)-Alkaline Phosphatase antibody produced in rabbit
Anti-Swine IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
Anti-HAMSTER IgG (H+L)-Alkaline Phosphatase antibody produced in rabbit
Anti-Rabbit IgG (H+L)-Alkaline Phosphatase antibody produced in chicken
Anti-Horse IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
Anti-Sheep IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
Anti-Human IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
Anti-Mouse IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
Anti-Bovine IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
Anti-Guinea Pig IgG (H+L)-Alkaline Phosphatase antibody produced in goat
Anti-Hamster IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
Anti-Chicken IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
Anti-Dog IgG (Fc specific)-Alkaline Phosphatase antibody produced in goat
Anti-Cat IgG (Fc specific)-Alkaline Phosphatase antibody produced in goat
Anti-Porcine IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
Anti-Rat IgG IgA IgM (H+L)-Alkaline Phosphatase antibody produced in goat
Anti-Rat IgG (Fc specific)-Alkaline Phosphatase antibody produced in goat
Anti-Human IgGIgA IgM (H+L)-Alkaline Phosphatase antibody produced in goat
Anti-Guinea Pig IgG (H+L)-Alkaline Phosphatase antibody produced in rabbit
Anti-Guinea Pig IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat
Anti-Pig IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
Anti-Horse IgG (Fc specific)-Alkaline Phosphatase antibody produced in goat
Anti-Cat IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
Anti-Rat IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
Anti-Dog IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
Anti-Rabbit IgG (Fc specific)-Alkaline Phosphatase antibody produced in goat
Anti-Guinea Pig IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
Anti-Ferret IgG IgA IgM (H+L)-Alkaline Phosphatase antibody produced in goat
Anti-goat IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
Anti-Horse IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
Anti-Swine IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
Anti-Mouse IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
AUTOCAMTIDE 2-RELATED INHIBITORY PEPTIDE, MYRISTOYLATED TRIFLUOROACETATE SALT
Anti-Human IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
Anti-Sheep IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
Anti-Rat IgA (α-chain specific)-Alkaline Phosphatase antibody produced in goat
Anti-Rabbit IgG (Fc specific)-Alkaline Phosphatase antibody produced in donkey
Anti-Mouse (λ-chain specific)-Alkaline Phosphatase antibody produced in rabbit
Anti-Rat IgM (μ-chain specific)-Alkaline Phosphatase antibody produced in goat
Anti-Bovine IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
Anti-Porcine IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
Anti-Chicken IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
Anti-Rat IgM (μ-chain specific)-Alkaline Phosphatase antibody produced in rabbit
Anti-Guinea Pig IgG (Fc specific)-Alkaline Phosphatase antibody produced in goat
Anti-Ferret IgA (α-chain specific)-Alkaline Phosphatase antibody produced in goat
Anti-Monkey IgA (α-chain specific)-Alkaline Phosphatase antibody produced in goat
Anti-Ferret IgG (γ-chain specific)-Alkaline Phosphatase antibody produced in goat
Anti-Ferret IgM (μ-chain specific)-Alkaline Phosphatase antibody produced in goat
Anti-Monkey IgM (μ-chain specific)-Alkaline Phosphatase antibody produced in goat
Anti-Monkey IgG (γ-chain specific)-Alkaline Phosphatase antibody produced in goat
Anti-Human IgG (γ-chain specific)-Alkaline Phosphatase antibody produced in rabbit | [Molecular Formula]
C64H116N22O19 | [MDL Number]
MFCD03453663 | [MOL File]
167114-91-2.mol | [Molecular Weight]
1497.74 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
H2O: soluble
| [form ]
lyophilized powder
| [color ]
white
| [Water Solubility ]
Soluble to 1 mg/ml in water |
| Hazard Information | Back Directory | [Uses]
Autocamtide 2-related inhibitory peptide has been used:
- To inhibit calmodulin kinase II (CaMKII) action in virulent Theileria infected macrophages
- To study its influence on oxidative stress associated with neural cell death after hypoxia-ischemia, using neonatal hippocampal slice cultures
- To quench the phosphorylation of recombinant synGA (GTPase-activating protein) induced by CaMKII
| [Uses]
Autocamtide-2-Related Inhibitory Peptide is a highly specific and potent inhibitor of CaMKII. | [Biological Activity]
synthetic peptide aip (autocamtide-2-related inhibitory peptide) is a nonphosphorylatable analog of autocamtide-2, which was identified to be a highly specific and potent inhibitor of calmodulin-dependent protein kinase ii (cam-kinase ii, camkii). camkii is a serine/threonine-specific protein kinase, which is modulated by the ca2+/calmodulin. | [Biochem/physiol Actions]
Calmodulin kinase II facilitates the calcium-dependent L-type calcium channels. Autocamtide 2-related inhibitory peptide action does not influence cAMP (cyclic adenosine monophosphate)-dependent protein kinase II, calmodulin-dependent protein kinase IV and protein kinase C. Increased expression of calmodulin kinase II is observed in structural heart disease, indicated by myocardial infarction. Thus, inhibition of calmodulin kinase II activity might serve as a protective effect against structural heart disease, as it is found to prevent cardiac hypertrophy, dilation and dysfunction. | [in vitro]
aip (1 mm) completely inhibited camkii activity, but did not affect camp-dependent protein kinase, calmodulin-dependent protein kinase iv and protein kinase c,. the inhibition was noncompetitive, and the action was caused by binding to the autophosphorylation site, which is distinc from that for the exogenous substrate. the ic50 for the autophosphorylation of cam ii is 100 nm [1]. | [in vivo]
mice treated with aip by transgenic expression of aip, were protected from fructose-rich diet-induced arrhythmogenesis, spontaneous contractions and spontaneous ca2+ release events [2]. intra-nucleus accumbens (nac) injection of aip could dose-dependently increase the hwl (hindpaw withdrawal latency) to noxious thermal and mechanical stimulation in rats with mononeuropathy [3]. | [IC 50]
40 nm for cam-kinase ii [1]. | [storage]
Store at -20°C | [References]
[1] ishida a1, kameshita i, okuno s, kitani t, fujisawa h. a novel highly specific and potent inhibitor of calmodulin-dependent protein kinase ii. biochem biophys res commun. 1995 jul 26;212(3):806-12.
[2] sommese l, valverde ca, blanco p, castro mc, rueda ov, kaetzel m, dedman j, anderson me, mattiazzi a, palomeque j. ryanodine receptor phosphorylation by camkii promotes spontaneous ca(2+) release events in a rodent model of early stage diabetes: the arrhythmogenic substrate. int j cardiol. 2016 jan 1;202:394-406.
[3] bian h, yu lc. intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase ii inhibitor aip induced antinociception in rats with mononeuropathy. neurosci lett. 2015 jul 10;599:129-32. |
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