| Identification | Back Directory | [Name]
TERT-BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE | [CAS]
167081-37-0 | [Synonyms]
trans-1-(Boc-aMino)-3-(hy...
tert-Butyl (trans-3-(hydroxymethyl)
trans-3-(Boc-amino)cyclobutanemethanol,97%
trans-3-(Boc-aMino)cyclobutaneMethanol, 97%
BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE
trans-1-(Boc-aMino)-3-(hydroxyMethyl)cyclobutane
TERT-BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE
tert-butyl (1r,3r)-3-(hydroxymethyl)cyclobutylcarbamate
tert-butyl N-[trans-3-(hydroxymethyl)cyclobutyl]carbamate
trans-1-(Boc-amino)-3-(hydroxymethyl)cyclobutane - SB7652
Carbamic acid, [3-(hydroxymethyl)cyclobutyl]-, 1,1-dimethylethyl ester, trans-
Carbamic acid, N-[trans-3-(hydroxymethyl)cyclobutyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C10H19NO3 | [MDL Number]
MFCD08166748 | [MOL File]
167081-37-0.mol | [Molecular Weight]
201.26 |
| Hazard Information | Back Directory | [Reactions]
Tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate is an crucial organic compound that can be used to synthesize 3-Amino-cyclobutaneMethanol hydrochloride.
 | [Synthesis]
To a stirred solution of methyl (1R,3R)-3-((tert-butoxycarbonyl)amino)cyclobutane-1-carboxylate (1.0 g, 4.4 mmol) in THF (20 mL) was added 3M lithium borohydride (9 mL, 9 mmol) at 0° C. Then the reaction mixture was heated and stirred at 60° C for 3 h. The reaction mixture was then transferred into dilute NaOH and the resulting mixture was extracted using ethyl acetate (3×50 mL). The combined organic layer was dried over anhydrous sodium sulfate and filtered. The filtrate was evaporated under reduced pressure and the crude product was purified using silica gel column chromatography (3% MeOH-DCM) to give tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate as a white solid (0.8 g, 91%).
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Alfa Aesar
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