| Identification | Back Directory | [Name]
(1R,2S)-2-fluorocyclopropanecarboxylic acid | [CAS]
167073-08-7 | [Synonyms]
Sitafloxacin Impurity 26
(1R,2S)-2-fluorocyclopropanecarboxylic acid
(1R,2S)-2-fluorocyclopropane-1-carboxylic acid
(1R,2S)-trans-2-Fluorocyclopropanecarboxylic acid 97%
Cyclopropanecarboxylic acid, 2-fluoro-, (1R-trans)- (9CI) | [Molecular Formula]
C4H5FO2 | [MDL Number]
MFCD19237658 | [MOL File]
167073-08-7.mol | [Molecular Weight]
104.08 |
| Chemical Properties | Back Directory | [Boiling point ]
202.3±33.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [pka]
4.00±0.11(Predicted) | [InChI]
InChI=1S/C4H5FO2/c5-3-1-2(3)4(6)7/h2-3H,1H2,(H,6,7)/t2-,3-/m0/s1 | [InChIKey]
HZQKMZGKYVDMCT-HRFVKAFMSA-N | [SMILES]
[C@H]1(C(O)=O)C[C@@H]1F |
| Hazard Information | Back Directory | [Synthesis]
Dissolve benzyl alcohol and allyl bromide in the solvent, add sodium hydride, and perform a condensation reaction to obtain allyl benzyl ether. The obtained allyl benzyl ether, dichlorofluoromethane, and sodium hydroxide solution are raw materials for carbene reaction to obtain 2-chloro-2-fluorocyclopropylmethyl benzyl ether. Subsequently, the obtained 2-chloro-2-fluorocyclopropylmethylbenzyl ether is hydrogenated and reduced to obtain 2-chloro-2-fluorocyclopropanemethanol. Sodium hypochlorite is added as an oxidizing agent to perform an oxidation reaction to obtain 2-chloro-2-fluorocyclopropanecarboxylic acid. Finally, diethylamine is added to perform a hydrogenation reduction reaction to obtain (1R,2S)-2-fluorocyclopropanecarboxylic acid.
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