| Identification | Back Directory | [Name]
LEU-LEU METHYL ESTER HYDROBROMIDE | [CAS]
16689-14-8 | [Synonyms]
LLME · HBr
H-Leu-Leu-OMe
Leu-Leu-Ome, HBr
H-LEU-LEU-OME HBR
LEU-LEU METHYL ESTER HYDROBROMIDE
Leu-Leu-Ome.HCl|H-Leu-Leu-Ome.HCl
L-Leucyl-L-Leucine methyl ester hydrobromide
Leu-Leu methyl ester hydrobromide >=97% (TLC)
(S)-Methyl 2-((S)-2-amino-4-methylpentanamido)-4-methylpentanoate hydrobromide | [Molecular Formula]
C13H27BrN2O3 | [MDL Number]
MFCD00216855 | [MOL File]
16689-14-8.mol | [Molecular Weight]
339.27 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO (up to 35 mg/ml) or in Water (up to 40 mg/ml) | [form ]
solid | [color ]
White | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month. |
| Hazard Information | Back Directory | [Description]
Leu-Leu-OMe (16689-14-8) is a lysosomal damaging agent (lysosomotropic). It is condensed into a membranolytic polymer via the transpeptidase action of cathepsin C within lysosomes.1,2 May be used to induce a lysosomal damage model in cells.3,4? LLOMe-induced lysosomal damage elicits ubiquitin puncta formation on lysosomes.1 Induces apoptosis in human mast cells via lysosome destabilization leaving fibroblasts and HEK-293 cells largely resistant.5 Induces lysophagy.4 | [Uses]
H-Leu-Leu-OMe·HBr is a useful research chemical compound used in the preparation of octapeptide derivatives and intermediates. | [storage]
Store at -20°C | [References]
1) Maejima et al. (2013), Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury; EMBO J., 32 2336
2) Fujita et al. (2013), Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin; J. Cell Biol., 203 115
3) Chauhan et al. (2016), TRIMS and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-directed Autophagy in Endomembrane Damage Homeostasis; Dev. Cell, 39 13
4) Otomo and Yoshimori (2017), Lysophagy: A Method for Monitoring Lysosomal Rupture Followed by Autophagy-Dependent Recovery; Methods Mol. Biol. 1594 141
5) Melo et al. (2011), Lysosomal membrane permeabilization induces cell death in human mast cells; Scand. J. Immunol., 74 354 |
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