| Identification | Back Directory | [Name]
METHOXYVERAPAMIL HYDROCHLORIDE | [CAS]
16662-46-7 | [Synonyms]
D600
D600, HCL
GALLOPAMIL
GALLOPAMIL HCL
(S)-Gallopamil
D 600 HYDROCHLORIDE
GALLOPAMIL HYDROCHLORIDE
(+/-)-METHOXYVERAPAMIL HCL
METHOXYVERAPAMIL HYDROCHLORIDE
(+/-)-METHOXYVERAPAMIL, HYDROCHLORIDE
(+/-)-VERAPAMIL, METHOXY-, HYDROCHLORIDE
VERAPAMIL, (+/-)-METHOXY-, HYDROCHLORIDE
[3-cyano-3-(3,4,5-trimethoxyphenyl)hex-6-yl]-(5,6-dimethoxyphenethyl)methylammonium chloride
(αS)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-α-isopropyl-3,4,5-trimethoxybenzeneacetonitrile
5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile hydrochloride
(S)-2-(3,4,5-Trimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]-2-(1-methylethyl)pentanenitrile
(αS)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4,5-trimethoxy-α-(1-methylethyl)benzeneacetonitrile
(+/-)-ALPHA-(3-[(2-[3,4-DIMETHOXYPHENYL]ETHYL)METHYLAMINO]PROPYL)-3,4,5-TRIMETHOXY-ALPHA-(1-METHYLETHYL)-BENZENEACETONITRILE HYDROCHLORIDE | [EINECS(EC#)]
240-704-7 | [Molecular Formula]
C28H41ClN2O5 | [MDL Number]
MFCD00058000 | [MOL File]
16662-46-7.mol | [Molecular Weight]
521.09 |
| Chemical Properties | Back Directory | [Melting point ]
145-148° | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 16.7 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 0.25 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Gallopamil hydrochloride is a somewhat more potent methoxy analog of calcium
channel blocker verapamil with a similar profile. It is useful in the treatment of
angina and auricular arrhythmia. | [Originator]
Knoll (W. Germany) | [Uses]
Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist[1]. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2]. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent[3]. | [Brand name]
Benpredil;Corapamil;PROCORUM. | [in vivo]
Gallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate[3].
| Animal Model: | Male Wistar rats weighing 290-370 g[3] | | Dosage: | 0.2 mg/kg | | Administration: | i.v.; 5 min | | Result: | Markedly reduced VT and totally prevented VF.
|
| [References]
[1] Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47(1):93-115. DOI:10.2165/00003495-199447010-00007
[2] Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9-14. DOI:10.1159/000137824
[3] Kirchengast M, et al. Reperfusion arrhythmias in closed-chest rats: the effect of myocardial noradrenaline depletion and Ca2(+)-antagonism. Clin Exp Pharmacol Physiol. 1991 Apr;18(4):217-21. DOI:10.1111/j.1440-1681.1991.tb01434.x |
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