| Identification | Back Directory | [Name]
Pyridoclax | [CAS]
1651890-44-6 | [Synonyms]
MR 29072
Pyridoclax
MR-29072;MR 29072
Pyridoclax(MR29072)
Pyridoclax (Synonyms: MR-29072)
5,6'-Di(pyridin-5-yl)-5'-methyl-3-((E)-2-phenylethenyl)-2,3'-bipyridine
3'-Methyl-3''-[(1E)-2-phenylethenyl]-3,2':5',2'':5'',3'''-quaterpyridine | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C29H22N4 | [MOL File]
1651890-44-6.mol | [Molecular Weight]
426.51 |
| Chemical Properties | Back Directory | [Boiling point ]
663.6±55.0 °C(Predicted) | [density ]
1.192±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.65±0.12(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Pyridoclax is a potential Mcl-1 inhibitor. | [IC 50]
Mcl-1 | [References]
[1] Gloaguen C, et al. First evidence that oligopyridines, α-helix foldamers, inhibit Mcl-1 and sensitize ovarian carcinoma cells to Bcl-xL-targeting strategies. J Med Chem. 2015 Feb 26;58(4):1644-68. DOI:10.1021/jm500672y
[2] Groo AC, et al. Comparison of 2 strategies to enhance Pyridoclax solubility: Nanoemulsion delivery system versus salt synthesis. Eur J Pharm Sci. 2017 Jan 15;97:218-226. DOI:10.1016/j.ejps.2016.11.025 |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|