| Identification | Back Directory | [Name]
SLMP53‐1 | [CAS]
1643469-17-3 | [Synonyms]
SLMP53‐1
Oxazolo[2,3-a]isoindol-5(9bH)-one, 2,3-dihydro-3-(1H-indol-3-ylmethyl)-9b-methyl-, (3S,9bR)- | [Molecular Formula]
C20H18N2O2 | [MOL File]
1643469-17-3.mol | [Molecular Weight]
318.37 |
| Chemical Properties | Back Directory | [Boiling point ]
561.5±50.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 250 mg/mL (785.25 mM; ultrasonic and warming and heat to 80°C) | [form ]
Solid | [pka]
17.07±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
SLMP53-1 is a wild-type and mutant p53 reactivator with promising antitumor activity. SLMP53-1 mediates the reprograming of glucose metabolism in cancer cells. SLMP53-1 depletes angiogenesis, decreasing endothelial cell tube formation and vascular endothelial growth factor (VEGF) expression levels[1][2]. | [storage]
Store at -20°C | [References]
[1]. Gomes S, et al. SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma. Cancers (Basel). 2019 Aug 10;11(8):1151.[2]. Ramos H, et al. SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner. Int J Mol Sci. 2020 Jan 17;21(2):596. |
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